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2005, Volume 21, Number 1-2, Page(s) 027-030     
[ Abstract (Turkish) ] [ PDF ] [ Similar Articles ]
PLEXIFORM FIBROHISTIOCYTIC TUMOUR: A CASE REPORT
Ahmet MİDİ, Tülin ÖZTÜRK, Cuyan DEMİRKESEN, Sergülen DERVİŞOĞLU
İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul
Keywords: Soft tissue, plexiform fibrohistiocytic tumour, CD68, CD34, smooth muscle actin, immunohistochemistry

Plexiform fibrohistiocytic tumour (PFHT) is a rare soft tissue neoplasm with low-grade nature. Histologically, it is characterized by a plexiform proliferation of mononuclear histiocyte-like cells, multinucleated osteoclast-like giant cells, and spindle fibroblast-like cells in variable proportions. We report a case of a 26-year-old woman with a PFHT on the forehead region. The patient had noticed solitary, hard, painless nodule with 7 mm diameter at her forehead region two months ago. The lesion was excised in another center and the material was diagnosed as fibroma. The lesion was recurred two weeks later and a second operation was carried out. Immunohistochemistry for CD68, CD34, smooth muscle actin were performed in Department of Pathology, Cerrahpaşa Medical Faculty. CD68 was positive in many of mononuclear macrophages and smooth muscle actin was positive in spindle fibroblast-like cells. The tumor cells were negative for CD34 and the findings were found to be consistent with the diagnosis of PFHT. Our case was worth to discuss because PFHT is a new entity and head and neck region is an unusual localization as compared to extremity.

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