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2009, Volume 25, Number 3, Page(s) 059-070
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DOI: 10.5146/tjpath.2009.01157 |
Gleason Grading System, Modifications and Additions to the Original Scheme |
Dilek ERTOY BAYDAR1, Jonathan I. EPSTEIN2 |
Department of Pathology, Hacettepe University, School of Medicine, ANKARA, TURKEY
Departments of Pathology, Urology and Oncology, Baltimore, The Johns Hopkins Hospital, MD, USA |
Keywords:
Prostate cancer, Gleason grading, Modification |
Histologic grade remains one of the most useful predictors of
prognosis of prostate cancer. The Gleason scoring is now the only
grading method recommended by the World Health Organization for
prostatic carcinoma. While the basic principles of the Gleason grading
remain relatively unchanged since it was established, several important
modifications have been recently proposed to solve the controversial
issues, to achieve higher concordance between the pathologists and
to increase the prognostic utility of the system. This review provides a
simplified approach to the application of the Gleason grading system
in contemporary pathology practice and gives an update of the recent
modifications taking into account several latest position papers.
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