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2009, Volume 25, Number 3, Page(s) 059-070     
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DOI: 10.5146/tjpath.2009.01157
Gleason Grading System, Modifications and Additions to the Original Scheme
Department of Pathology, Hacettepe University, School of Medicine, ANKARA, TURKEY
Departments of Pathology, Urology and Oncology, Baltimore, The Johns Hopkins Hospital, MD, USA
Keywords: Prostate cancer, Gleason grading, Modification

Histologic grade remains one of the most useful predictors of prognosis of prostate cancer. The Gleason scoring is now the only grading method recommended by the World Health Organization for prostatic carcinoma. While the basic principles of the Gleason grading remain relatively unchanged since it was established, several important modifications have been recently proposed to solve the controversial issues, to achieve higher concordance between the pathologists and to increase the prognostic utility of the system. This review provides a simplified approach to the application of the Gleason grading system in contemporary pathology practice and gives an update of the recent modifications taking into account several latest position papers.

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