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2009, Volume 25, Number 3, Page(s) 071-077
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DOI: 10.5146/tjpath.2009.01158 |
Correlation Between Fuhrman Nuclear Grade and Stage with Survival in Renal Cell Carcinoma |
Evrim KUŞ1, Kürşat YILDIZ1, Özdal DİLLİOĞLUGİL2 |
Kocaeli Üniversitesi, Tıp Fakültesi, 1Patoloji, 2Üroloji Anabilim Dalları, KOCAELİ, TÜRKİYE Departments of 1Pathology and 2Urology, Kocaeli University, Faculty of Medicine, KOCAELİ, TURKEY |
Keywords:
Renal cell carcinoma, Survival, Fuhrman grade, Stage |
Objective: Our aim was to find out the correlation between
histopathological findings and survival of patients with renal cell
carcinoma.
Material and Method: We examined 114 cases diagnosed as renal cell
carcinoma at the Pathology Department in 1997 - 2007. We explored
the correlation of histological type, size, Fuhrman nuclear grade,
renal capsule invasion, renal vein and lymphatic/vascular invasion,
tumoral necrosis and stage with survival.
Results: Histological subtypes were determined as clear cell in 101
cases (88,6%) , papillary in 9 cases (7,9%), and chromophobe renal cell
carcinoma in 4 cases (3,5%). Reliable follow-up data were available in
96 of 114 cases. 74 of them (77,1%) were alive and 22 of them (22,9%)
had died related to renal cell carcinoma. The mean follow-up time
was 21,5 months with a wide range between 2 days and 87 months. 5
year survival was 61,3 months, and its probability was 58,2%.
Conclusion: We provide statistical results compatible with the recent
literature in regard to high Fuhrman nuclear grade, advanced stage,
necrosis, capsule invasion, microvascular invasion and lymph node
invasion decreasing the survival time.
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