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2009, Volume 25, Number 3, Page(s) 118-121
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DOI: 10.5146/tjpath.2009.01165 |
Micronodular Thymoma with Lymphoid Stroma: Case Report |
Ebru ÇAKIR1, Funda DEMİRAĞ1, Göktürk FINDIK2, Sadi KAYA2 |
Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, 1Patoloji ve 2Göğüs Cerrahisi Bölümleri, ANKARA, TÜRKİYE
Departments of 1Pathology and 2Chest Surgery, M.H. Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, ANKARA, TURKEY |
Keywords:
Micronodular thymoma, Histology, Immunohistochemistry |
A 77-year-old female with a history of hypertension was admitted
to our hospital for cough lasting for 1 year. Computed tomography
showed a 5x4x3 cm nodular anterior mediastinal mass. A complete
surgical resection of the tumor was performed by median sternotomy.
Macroscopically the mass 5x4x3 cm was surrounded by a thin capsule.
Microscopically a tumoral tissue characterized by a proliferation
of multiple epithelial nodules seperated by an abundt lymphoid
tissue was seen. The surrounding lymphoid tissue contained a dense
proliferation of small lymphocytes forming lymphoid follicles with
prominent germinal centers. Immunohistochemically, the epithelial
cells were positive for pancytokeratin and CK5/6, lymphoid follicles
were positive for CD20 and few scattered lymphoid cells in and
around the nodules were positive for CD 3 and CD5. Histopathologic
diagnosis was micronodular thymoma.
It is important to differentiate these tumors from other types of
thymomas because of their association with low grade lymphomas.
A rare case of micronodular thymoma was presented and discussed
with the literature.
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