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2010, Volume 26, Number 1, Page(s) 025-030
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DOI: 10.5146/tjpath.2010.00991 |
Ki-67, p53, Bcl-2 and Bax Expression in Urothelial Carcinomas of Urinary Bladder |
Nilay ŞENTÜRK1, Zafer AYBEK2, Ender DÜZCAN1 |
1Departments of Pathology, Pamukkale University, Faculty of Medicine, DENIZLI, TURKEY
2Departments of Urology, Pamukkale University, Faculty of Medicine, DENIZLI, TURKEY |
Keywords:
Bladder cancer, p53, Ki-67, Bcl-2, Bax |
Objective: The most important predictive parameter for the biological
behavior of urothelial carcinomas except depth of invasion is the
histological grade of the tumor. However, crucial discordances arise
between pathologists because of subjectivity in histological grading
schemes and these discordances cause difficulties especially in lowgrade
tumors. The number of studies aiming to predict the risk of
recurrence and progression in urothelial carcinomas has therefore
increased in recent years. Our aim in this study was to evaluate the
relation of histopathological and clinical characteristics of urothelial
carcinomas with proliferation and apoptosis markers and to determine
predictive parameters for their biological behavior.
Material and Method: This study included 84 previously
diagnosed cases of urothelial carcinoma of the urinary bladder.
Immunohistochemical expressions of Ki-67, p53, Bcl-2, and Bax were
examined in each case.
Results: Expressions of Ki-67 and p53 determined a significant
relationship between pathological stage and histological grade of
the cases. There was no significant relationship between the other
apoptotic markers (Bcl-2, and Bax) and clinical or morphological
parameters.
Conclusion: We concluded that the evaluation of Ki-67 and p53
expression combined with pathological stage and histological grade
may give more accurate information about the biological behavior of
urothelial carcinomas of the urinary bladder.
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