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2010, Volume 26, Number 1, Page(s) 038-043     
[ Abstract (Turkish) ] [ PDF ] [ Similar Articles ]
DOI: 10.5146/tjpath.2010.00993
Correlation Between Cytological and Histopathological Diagnosis in Premalignant Lesions of the Cervix
Cemile YEŞİL1, Sevgen ÖNDER2, Kübra BOYNUKALIN3, Özlem ERGÜL4, Pınar FIRAT2, Gamze Mocan KUZEY2, Alp USUBÜTÜN2
1S.B. Ankara Atatürk Eğitim ve Araştırma Hastanesi, ANKARA, TÜRKİYE
2Hacettepe Üniversitesi, Tıp Fakültesi, Patoloji, Anabilim Dalı, ANKARA, TÜRKİYE
3Hacettepe Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalları, ANKARA, TÜRKİYE
4S.B. Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Patoloji Bölümleri, ANKARA, TÜRKİYE

1Departments of Pathology, M.H. Atatürk Education and Research Hospital, ANKARA, TÜRKİYE
2Departments of Pathology, Hacettepe University, Faculty of Medicine, ANKARA, TÜRKİYE
3Departments of Gynecology and Obstetrics, Hacettepe University, Faculty of Medicine, ANKARA, TURKEY
4Departments of M.H. Dışkapı Yıldırım Beyazıt Education and Research Hospital, ANKARA, TÜRKİYE

Keywords: Cervix, Smear, Biopsy, Cytodiagnosis, Histopathology

Objective: Providing the consistency between the results from cytologic examination (Pap test) of cervical lesions with those of follow-up biopsies is an important quality control method. We investigated diagnostic difficulties and reasons in cytohistopathologic practice in this study.

Material and Method: We included 43 patients cytologically diagnosed as LSI L or HSI L between 2001-2007 with negative subsequent biopsy results.

Results: We were able to gain access to the cytological material of 37 cases and 9 of these received different diagnoses from the initial diagnoses. Re-evaluation of the biopsies provided a diagnosis of SI L in 9 of 43 cases.

Conclusion: The reason for the inconsistent histopathologic diagnoses was misinterpreting in 6 cases and microscopic sampling error due to the lack of serial cuts in 3 cases. We detected %21 false negatives on biopsies mostly as a result of misinterpretation. The squamocolumnar junction was not present in 11 cases that had previously been diagnosed as negative. In conclusion, serial cuts must be evaluated by an experienced pathologist specialized in gynecopathology in cervical biopsies with positive cytology results and the absence of the squamocolumnar junction must be reported.

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