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2010, Volume 26, Number 3, Page(s) 200-208     
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DOI: 10.5146/tjpath.2010.01025
Differences in the Cytological Features of Atypical Adenomatous Hyperplasia and Low-Grade Prostatic Adenocarcinoma
Ahmet MİDİ1, Tülay TECİMER2, Süheyla BOZKURT2, Naziye ÖZKAN2
1Department of Pathology, Maltepe University, Faculty of Medicine, İSTANBUL, TURKEY
2Department of Pathology, Marmara University, Faculty of Medicine, İSTANBUL, TURKEY
Keywords: Prostate, Hyperplasia, Adenocarcinoma

Objective: The aim of this study was to review the histological features and to define parameters distinguishing atypical adenomatous hyperplasia from prostatic adenocarcinoma grade 1 and 2. We evaluated 14 parameters related with cytological properties.

Material and Method: We found 11 atypical adenomatous hyperplasia (22 foci) and 15 prostatic adenocarcinoma grade 1 and 2 (22 foci) lesions in 105 radical prostatectomy specimens. Basal cell-specific keratin (34βE12) was applied and based on the fact that prostatic adenocarcinoma grade 1 and 2 lesions do not have basal cells we grouped the lesions as atypical adenomatous hyperplasia and prostatic adenocarcinoma grade 1 and 2.

Results: Statistically significant differences were found between atypical adenomatous hyperplasia and prostatic adenocarcinoma grade 1 and 2 lesions for some parameters including the largest nuclear diameter, nuclear location, 1-2 μm nucleolus, > 2 μm nucleolus, and nuclei containing multiple nucleoli. We found similar properties between the two lesions for the following parameters: irregularity of nuclear membrane, median diameter of the nucleolus, chromatin pattern, pynotic nucleus, nuclear pleomorphism, < 1 μm nucleolus nucleolar margination, and the ratio of nucleus to cytoplasm and the appearance of cytoplasm in the secretory cells.

Conclusion: Evaluation of the overall histomorphological criteria is important in the differentiation of atypical adenomatous hyperplasia and prostatic adenocarcinoma grade 1 and 2 lesions.


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