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2011, Volume 27, Number 3, Page(s) 196-203     
[ Abstract (Turkish) ] [ PDF ] [ Similar Articles ]
DOI: 10.5146/tjpath.2011.01075
Correlation of HER 2/neu Gene Amplification with Immunohistochemistry and Other Prognostic Factors in Breast Carcinoma
Saime SEZGİN RAMADAN1, Özlem YAPICIER1, Selçuk KİHTİR2, Ayhan ERDEMİR2, Tuğser Hakan DOĞAN3, İsmail Necdet Hakkı ÜSKENT4, Haluk ONAT4, Metin ÇAKMAKÇI2
1Department of Pathology, Anadolu Medical Center, KOCAELİ, TURKEY
2Department of General Surgery, Anadolu Medical Center, KOCAELİ, TURKEY
3Department of Radiology, Anadolu Medical Center, KOCAELİ, TURKEY
4Department of Medical Oncology, Anadolu Medical Center, KOCAELİ, TURKEY
Keywords: Breast, Carcinoma, HER-2/neu, Immunohistochemistry, Fluorescent in situ hybridization

The purpose of this study was to determine relationship between HER-2/neu status and estrogen receptor, progesterone receptor, grade and age by comparing fluorescence in situ hybridization and immunohistochemistry. One hundred invasive breast carcinomas were reviewed and fluorescence in situ hybridization analysis was performed in all cases. Immunohistochemical scores showed a perfect concordance with fluorescence in situ hybridization amplification ratios (p<0.0001). The results indicated a significant correlation between HER-2/neu and grade, but an inverse relationship between HER-2/neu and hormone receptors. In women aged ≤45 years, an inverse relationship between HER-2/neu and progesterone receptor was found and no association was noted between HER-2/neu and other factors. In women aged >45 years, the results indicated a significant correlation between HER-2/neu and grade, and there was an inverse relationship between HER-2/neu and hormone receptors.

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