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2011, Volume 27, Number 3, Page(s) 221-229     
[ Abstract (Turkish) ] [ PDF ] [ Similar Articles ]
DOI: 10.5146/tjpath.2011.01079
General Evaluation of Hepatectomy and Hepatocellular Carcinoma Cases
Nuray BAŞSÜLLÜ1, İlknur TÜRKMEN1, Onur YAPRAK2, Murat DAYANGAÇ2, Tolga DEMİRBAŞ2, Necdet GÜLER2, Süleyman URAZ3, Murat AKYILDIZ4, Engin CİĞERCİOĞULLARI5, Yaman TOKAT2, Yıldıray YÜZER2, Gülen BÜLBÜL DOĞUSOY1
1Department of Pathology, İstanbul Bilim University, Faculty of Medicine, İSTANBUL, TURKEY
2Department of General Surgery Organ Transplantation, Şişli Florence Nightingale Hospital, İSTANBUL, TURKEY
3Department of Gastroenterology, Şişli Florence Nightingale Hospital, İSTANBUL, TURKEY
4Department of Gastroenterology, İstanbul Bilim University, Faculty of Medicine, İSTANBUL, TURKEY
5Department of Medical Pathology, Ağrı Maternity and Pediatric Hospital, AĞRI, TURKEY
Keywords: Transplantation, Cirrhosis, Hepatocellular carcinoma, Etiology

Objective: Although the clinical and histopathological findings of hepatocellular carcinoma are well described, there are few national studies. In this study, we aimed to investigate the relationship between these findings in total or partial hepatectomy specimens in our series.

Material and Method: We first collected 190 cases of total or partial hepatectomies performed because of hepatocellular carcinoma, cirrhosis or other disorders from the archives of Pathology. After re-examining the histopathological and clinical features such as age, gender and etiology, the relationship between them and serology results were statistically analyzed using the chi square and Multiple Comparison Tests.

Results: Among 190 cases, there were 168 (88.5%) total and 18 (9.5%) partial hepatectomies and 4 (2%) tumorectomy or metastasectomy cases. After gross and microscopic examination, 170 (89.5%) cases had a diagnosis of cirrhosis, 85 (44.7%) hepatocellular carcinoma, 3 parasitic cyst, 7 metastasis, 1 hepatoblastoma, 1 hepatocellular adenoma, 2 cholangiocarcinoma, 2 Budd Chiari Syndrome, 1 focal nodular hyperplasia, 1 cavernous hemangioma, and 2 acute fulminant hepatitis.

Among the hepatocellular carcinoma cases, 53 had Hepatitis B virus, 15 Hepatitis C virus , 3 Hepatitis B virus and Hepatitis C virus, and 3 Hepatitis B virus and Hepatitis delta virus etiology, while 6 were alcoholic and 4 were due to other causes. Among cirrhosis patients, 84 (49.4%) had hepatocellular carcinoma. The male to female ratio of hepatocellular carcinoma cases was 74/11. The mean age was 55 and the median age 56.7.

Conclusion: The results of this study demonstrated that the most common hepatic disorder was cirrhosis due to Hepatitis B virus in the hepatectomy specimens of our series that mostly consisted of total hepatectomies performed for transplantation where 50% had hepatocellular carcinoma.


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