SCImago Journal & Country Rank
This journal is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE)
2006, Volume 22, Number 2, Page(s) 087-091     
[ Abstract (Turkish) ] [ PDF ] [ Similar Articles ]
The use of Ber-EP4 antigen in the differential diagnosis of basosquamous carcinoma from squamous and basal cell carcinoma
Nermin KARAHAN1, Şirin BAŞPINAR2, Mehmet YILDIRIM3, İbrahim BARUT4
1Department of Pathology, Suleyman Demirel University School of Medicine, ISPARTA
2Department of Pathology, Egirdir Bone Joint Diseases Treatment and Rehabilitation Hospital, ISPARTA
3Department of Dermatology, Suleyman Demirel University School of Medicine, ISPARTA
4Department of Surgery, Suleyman Demirel University School of Medicine, ISPARTA
Keywords: Ber-EP4, basal cell carcinoma, basosquamous carcinoma, squamous cell carcinoma

Basal cell and squamous cell carcinoma of skin are common tumors which can be easily distinguished on hematoxylin and eosin stained sections, but basosquamous carcinoma is a controversial entity. The aim of our study was to distinguish basal cell carcinoma and basosquamous carcinoma using Ber-EP4, immunohistochemically in 52 skin tumors. Twenty basal cell carcinomas, 20 squamous cell carcinomas, 10 basosquamous carcinomas and 2 collision tumors of the skin were stained with Ber-EP4 immunohistochemically. All basal cell carcinomas were stained strongly and diffusely with Ber-EP4, whereas squamous cell carcinomas were not, and basosquamous carcinomas were partially stained. Our results suggest that, distinction of basal cell carcinoma and basosquamous carcinoma can be achieved with routine immunohistochemical Ber-EP4 staining.

[ Abstarct (Turkish) ] [ PDF ] [ Similar Articles ]