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2012, Volume 28, Number 1, Page(s) 024-030
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DOI: 10.5146/tjpath.2012.01093 |
Childhood Fibroblastic and Myofibroblastic Tumors: A Multicenter Documentation and Review of the Literature |
Ayper KAÇAR1, İrem PAKER2, Diclehan ORHAN3, Aylar POYRAZ4, Aylin OKÇU HEPER5, Nilüfer ARDA6, Esin BODUROĞLU6 |
1Department of Pathology, Ankara Children's Hematology and Oncology Research and Training Hospital, ANKARA, TURKEY
2Department of 2nd Pathology, Dışkapı Yıldırım Beyazıt Research and Training Hospital, ANKARA, TURKEY
3Department of Child Health and Diseases, Pediatric Pathology Unit, Hacettepe University, Faculty of Medicine, ANKARA, TURKEY
4Department of Pathology, Gazi University, Faculty of Medicine, ANKARA, TURKEY
5Ankara University, Faculty of Medicine, ANKARA, TURKEY
6Dr. Sami Ulus Child Diseases Research and Training Hospital, ANKARA, TURKEY |
Keywords:
Neoplasms, Fibrous tissue, Pediatric, Infant |
Objective: In this study, we aimed to give a documentation of 37 cases
of childhood fibroblastic/myofibroblastic tumors retrieved from the
archives of 6 reference centers in Ankara along with a comprehensive
review on the subject.
Material and Method: A retrospective archive search was carried out
for the period between 2006-2010 in 6 reference centers in Ankara
covering patients with ages ranging between 0-18 years. All the
tumors categorized under fibroblastic and myofibroblastic group
according to World Health Organization criteria were collected.
Results: The study comprised 407 soft tissue tumors in total.
Fibroblastic/myofibroblastic tumors constituted 9,1 % (37 cases) of
these tumors. According to histopathology; 16 cases were categorized
as fibromatosis, 8 cases as inflammatory myofibroblastic tumor,
6 cases as infantile fibrous hamartoma, 3 cases as nodular fasciitis
and 2 cases as infantile myofibroblastic tumor/myofibromatosis and
1 case as cranial fasciitis. The only malignant case was an infantile
fibrosarcoma.
Conclusion: Infantile fibrosarcoma was lower than reported series
and a male predominance was noted. The low incidence of newly
described entities as well suggests that these tumors may have been
unrecognized.
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