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2013, Volume 29, Number 2, Page(s) 146-149     
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DOI: 10.5146/tjpath.2013.01167
Diffuse Lipid İnfiltration and Squamous Metaplasia Accompanying Amyloid Goiter: Case Report
Remziye EREN1, Hamide SAYAR1, Harun ÇIRALIK1, Fikret EZBERCİ2
1Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi , Patoloji, Anabilim Dalı , KAHRAMANMARAŞ, TÜRKİYE
2Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı , KAHRAMANMARAŞ, TÜRKİYE
1Department of Pathology, Kahramanmaraş Sütçü İmam University, Faculty of Medicine, KAHRAMANMARAŞ, TURKEY
2Department of General Surgery, Kahramanmaraş Sütçü İmam University, Faculty of Medicine, KAHRAMANMARAŞ, TURKEY
Keywords: Amyloid, Thyroid diseases, Familial Mediterranean fever

Systemic amyloidosis is one of the serious complications of Familial Mediterranean Fever (FMF). Amyloid accumulation secondary to FMF can cause pressure symptoms in thyroid gland rarely. A 17-year-old male patient with the diagnosis of FMF performed the complaints of dyspnea during his follow-up period. He has demonstrated a rapidly increasing mass localized in front of his neck within the last three months that was diagnosed as a diff use, hyperplasic and pressuring thyroid gland. Total thyroidectomy was performed.

Histopathological investigation of the material obtained aft er thyroidectomy revealed diff use lipid infiltration in parenchyma, intense amyloid accumulation around and between the follicles that caused pressure on the follicles, and cystic areas in the tissue. Squamous metaplasia foci in cyst epithelium were detected. Upon these findings the case was diagnosed as amyloid goiter accompanied by metaplastic variations. In conclusion, it can be appropriate to take into account the possibility that metaplastic variations could accompany amyloid goiter in patients with long-term FMF.

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