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2013, Volume 29, Number 3, Page(s) 210-216     
[ Abstract (Turkish) ] [ PDF ] [ Similar Articles ]
DOI: 10.5146/tjpath.2013.01188
HPV Types in Turkey: Multicenter Hospital Based Evaluation of 6388 Patients in Turkish Gynecologic Oncology Group Centers
Polat DURSUN1, Ali AYHAN1, Levent MUTLU1, Mete ÇAĞLAR1, Ali HABERAL1, Taygun GÜNGÖR2, Mustafa ÖZAT2, Emre ÖZGÜ2, Anıl ONAN3, Çağatay TAŞKIRAN3, Haldun GÜNER3, Hakan YETİMALAR4, Burcu KASAP4, Kunter YÜCE5, M. Coşkun SALMAN5, Berkan SAYAL5, Selen DOĞAN5, Müge HARMA6, Mehmet HARMA6, Mustafa BASARAN6, Hüseyin AYDOĞMUŞ7,Yusuf ERGÜN7, Salim ŞEHİRALİ8, Emre GÜLTEKİN8, Şükran KÖSE8, Yusuf YILDIRIM8, Müfit YENEN9, Murat DEDE9, İbrahim ALANBAY9, Rıza KARACA9, Jale METİNDİR10, Levent KESKİN11, Işık ÜSTÜNER11, Filiz AVŞAR11, Hasan YÜKSEL12, Selim KIRDAR12
1Department of Obstetrics and Gynecology, Başkent University, Faculty of Medicine, ANKARA, TURKEY
2Zekai Tahir Burak Maternity Hospital, ANKARA, TURKEY,
3Gazi University, Faculty of Medicine, ANKARA, TURKEY
4Atatürk Education and Research Hospital, İZMİR, TURKEY
5Hacettepe University, Faculty of Medicine, ANKARA, TURKEY
6Karaelmas University, Faculty of Medicine, ZONGULDAK, TURKEY
7Ankara Education and Research Hospital, ANKARA, TURKEY
8Ege Maternity Hospital, İZMİR, TURKEY
9Gülhane Military Medical Academy, ANKARA, TURKEY
10Department of Gynecologic Oncology, Ankara Oncology Hospital, ANKARA, TURKEY
11Atatürk Education and Research Hospital, ANKARA, TURKEY
12Adnan Menderes University, Faculty of Medicine, AYDIN, TURKEY
Keywords: Human papillomavirus DNA tests, Mass screening, Uterine cervical neoplasms, Vaginal smears, Turkey

Objective: To evaluate the prevalence of HPV DNA and cervical cytological abnormalities, to compare cervical cytology results and HPV DNA and to define HPV types distribution in a large series of Turkish women who have undergone HPV analysis in hospitals that are members of the Turkish Gynecological Oncology Group.

Material and Method: Between 2006 and 2010, a total of 6388 patients’ data was retrospectively evaluated at 12 healthcare centers in Turkey. Demographic characteristics, cervical cytology results, HPV status and types were compared.

Results: The mean age of the patients was 38.9±10.2. Overall, 25% of the women were found to be HPV positive. Presence of HPV-DNA among patients with abnormal and normal cytology was 52% and 27%, respectively. There was significant diff erence with respect to decades of life and HPV positivity (p < 0.05). HPV was positive in (within the HPV (+) patients) 37%, 9%, 27%, 20%, 22%, and 41% of the ASCUS, ASC-H, LSIL HSIL, glandular cell abnormalities, and SCC cases respectively The most common HPV types in our study were as follows; HPV 16 (32%), HPV 6 (17%), HPV 11 (9%), HPV 18 (8%), HPV 31 (6%), HPV 51 (5%), HPV 33 (3%).

Conclusion: In this hospital based retrospective analysis, HPV genotypes in Turkish women with normal and abnormal cytology are similar to those reported from western countries. Further population based prospective multicenter studies are necessary to determine non-hospital based HPV prevalence in Turkish women.


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