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2014, Volume 30, Number 1, Page(s) 018-022
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DOI: 10.5146/tjpath.2013.01202 |
Are Mammaglobin and Gcdfp-15 Sensitive Markers for Diagnosis of Metastatic Basal-Like Triple Negative Breast Carcinomas? |
Nasser RAKHSHANİ, Arash DARYAKAR |
Department of Pathology, Tehran University of Medical Sciences, Firuzgar Hospital, TEHRAN, IRAN ISLAMIC REPUBLIC |
Keywords:
Mammaglobin, Breast cancer, Immunohistochemistry, Differential diagnosis |
Objective: There are small studies on expression of mammaglobin
and GCDFP-15 for detection of basal-like triple negative breast
cancer. This type of cancer has shorter survival and higher mortality
rate. There must be reliable markers for detecting this type of tumor
especially in metastatic cases with unknown origin.
Material and Method: In this study we assessed 66 paraffin
blocks of breast cancers previously diagnosed as triple negative
subtype in Mehr hospital (Tehran, Iran) by tissue microarray and
immunohistochemistry technique for expression of mammaglobin
and GCDFP-15.
Results: GCDFP-15 was positive in 12 cases (18.2%) and the other
54 (81.8%) cases remained negative. Mammaglobin was positive only
in 6 cases (9.1%) and the remaining 60 (90.9%) cases were negative.
Conclusion: According to recent studies and our findings, there is no
useful immunohistochemical marker for detection of breast source in
cases of metastatic triple negative breast cancer with unknown origin
and we must try hard to discover more accurate immunohistochemical
markers for these highly metastatic breast cancers.
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