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2014, Volume 30, Number 2, Page(s) 137-141     
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DOI: 10.5146/tjpath.2013.01206
Osteosarcoma Arising from a Haemangioma: Case Report and Review of the Literature
Paul MALLƯNSON1, Tyler COUPAL2, Malcolm HAYES3, Paul CLARKSON4, Peter MUNK1, Hugue OUELLETTE1
1Department of Radiology, Vancouver General Hospital/University of British Columbia, VANCOUVER/BC, CANADA
2McMaster University, De Groote Medical School, HAMILTON/ONTARIO, CANADA
3Departments of Pathology, BC Cancer Agency, VANCOUVER BC, CANADA
4Departments of Surgery, BC Cancer Agency, VANCOUVER BC, CANADA
Keywords: Osteosarcoma, Neoplastic cell transformation, Hemangioma

To create awareness of the benign lesions from which osteosarcoma may arise.

Osteosarcoma is a rare tumour of bone the etiology of which is poorly understood, but it may arise from benign lesions. Malignant transformation in hemangiomas, in the absence of prior radiation, is exceedingly rare and the resulting neoplasm is usually an angiosarcoma. We report the case of a 30-year-old woman where investigation for thigh pain revealed a distal femoral hemangioma. She represented with pain and mass 18 years later, leading to a confirmed diagnosis of osteosarcoma at the same site.

Osteosarcomas may arise from a variety of benign lesions. In this article we report the case of a histologically confirmed hemangioma which subsequently underwent malignant change into an osteosarcoma.


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