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2017, Volume 33, Number 3, Page(s) 248-250
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DOI: 10.5146/tjpath.2014.01259 |
A Translocation Renal Cell Carcinoma with Skeletal Muscle Metastasis in a Child |
Gülen TÜYSÜZ1, Nihal ÖZDEMİR1, Haluk EMİR2, Haydar DURAK3, Sergülen DERVİŞOĞLU3, İbrahim ADALETLİ4, Hilmi APAK1 |
1Departments of Pediatric Hematology Oncology, İstanbul University, Cerrahpaşa Medical Faculty, İSTANBUL, TURKEY
2Departments of Pediatric Surgery, İstanbul University, Cerrahpaşa Medical Faculty, İSTANBUL, TURKEY
3Departments of Pathology, İstanbul University, Cerrahpaşa Medical Faculty, İSTANBUL, TURKEY
4Departments of Radiology, İstanbul University, Cerrahpaşa Medical Faculty, İSTANBUL, TURKEY |
Keywords:
Translocation renal cell carcinoma, Pediatric, Skeletal muscle, Metastases |
Renal cell carcinoma is a tumor that is well known for a high rate
of metastasis to several locations like the lung, liver and bones.
Skeletal muscle is a rare location for dissemination of the disease.
Herein, we describe a 7-year-old boy who presented with flank pain.
On physical examination, an abdominal mass located on the left
kidney as well as a solid palpable lesion on the left upper arm were
detected. Total nephrectomy with subsequent excision of the arm
mass was performed. Pathology examination revealed presence of
translocation renal cell carcinoma. The patient received α-interferon
followed by multikinase inhibitor (Sorafenib) treatment but was lost
due to progressive disease. This is the first description of a pediatric
patient with skeletal muscle metastases of translocation renal cell
carcinoma in the literature.
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