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2015, Volume 31, Number 1, Page(s) 009-015
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DOI: 10.5146/tjpath.2014.01277 |
Metastasis-Associated Protein 1 Expression in Oral Squamous Cell Carcinomas: Correlation with Metastasis and Angiogenesis |
Azadeh ANDISHEHTADBIR1, Ali Dehghani NAJVANI1, Soheil PARDIS1, Zohreh Jafari ASHKAVANDI1, Mohammad Javad ASHRAF2, Bijan KHADEMI3, Fereshteh KAMALI1 |
1Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, SHIRAZ, IRAN
2Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, SHIRAZ, IRAN
3Department of Otolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, SHIRAZ, IRAN |
Keywords:
MTA-1 protein, Squamous cell carcinoma, Immunohistochemistry, Metastasis, Head and neck neoplasms |
Objective: Metastasis-associated protein 1 (MTA1) has been associated
with poor prognosis in several carcinomas. Recent investigation has
found that in different tumors, MTA1 protein significantly correlates
with tumor angiogenesis, suggesting that MTA1 may be a possible
angiogenesis-promoting molecule in malignant tumors. Thus, the
current study was performed to determine the role of MTA1 protein
in the biological behavior of oral squamous cell carcinoma and its
relation with tumor angiogenesis.
Material and Method: In this study, 44 oral squamous cell carcinomas
and 15 normal epitheliums were reviewed by IHC staining for MTA1
and CD105.
Results: Frequency of MTA1 expression in SCCs was recorded as
97.7%, which was significantly higher than that of the control group
(33.3%). Mean percentage of MTA1 expression in oral squamous
cell carcinomas was 76.88 ± 25.33% which was significantly higher
than that of the control group (22.81 ±10.83). Our data showed a
correlation between MTA1 expression with lymph node metastasis,
tumor size and, stage. Evaluation of the correlation between MTA1
protein expression and micro vessel density showed that high micro
vessel density was detected more frequently in tumors with MTA1
protein overexpression than in those without overexpression.
Conclusion: In the present study, high expression of the MTA1 protein
was seen in oral squamous cell carcinoma, and was closely associated
with tumor progression and increased tumor angiogenesis. The
findings may indicate that MTA1 protein has clinical potentials as
a useful indicator of progressive phenotype, a promising prognostic
predictor to identify patients with poor prognosis and may be a
potential novel therapeutic target of anti-angiogenesis for patients
with oral squamous cell carcinoma.
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