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2016, Volume 32, Number 1, Page(s) 008-014     
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DOI: 10.5146/tjpath.2015.01342
The Relation of Parafibromin Expression with Clinicopathological Factors in Invasive Breast Carcinomas
Serap KARAARSLAN1, Berhan GENÇ2, Ahmet NART3, İsmail BÖREKÇİ3, Mehmet Hüsnü BUĞDAYCI1
1Department of Pathology, Şifa University Faculty of Medicine, İZMİR, Turkey
2Department of Radiology Şifa University Faculty of Medicine, İZMİR, Turkey
3Department of General Surgery Şifa University Faculty of Medicine, İZMİR, Turkey
Keywords: Breast carcinoma, Immunohistochemistry, Lymph nodes, Metastasis, Parafibromin

Objective: We aimed to find the relationship between parafibromin expression and clinicopathologic variables of breast carcinoma.

Material and Method: Ninety-seven cases of invasive breast carcinoma diagnosed at our department between the years 2010–2013 were included in the study. The parafibromin expression state was compared with the estrogen receptor, progesterone receptor, cerbB2, Ki67 results, and the clinicopathological variables.

Results: Among 97 breast carcinoma cases, 66 (68%) were invasive ductal carcinoma. The average age was 54.3 (min:25, max:100), and the average tumor size was 31.1 mm (min:7, max:120). Lymph node metastasis was detected in 58% of the cases. Eleven were diagnosed with metastasis amongst 77 cases whose distant metastasis data could be reached. Eleven cases were lost due to breast carcinoma. As the tumor grade increased, the possibility of distant metastasis and lymph node metastasis increased as well (p=0.04, p=0.05, respectively). The mean follow-up duration of the cases was 26.6}9.8 (min. 6, max. 53) months, and there was no significant difference in survival between the other variables. Of the cases, 21.6% were negative, 9.3% were (+) positive, 11.3% were (++) positive and 57.7% were (+++) positive for parafibromin. It was found that there was an inverse correlation between the Ki67 proliferation index and lymph node metastasis and the parafibromin expression (p=0.018, p=0.029, respectively).

Conclusion: We suggest that parafibromin may be a possible prognostic and predictive parameter for breast carcinomas. As the data on this matter in the literature is limited, it would be beneficial to investigate the matter and evaluate its relationship with survival in larger series.


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