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2018, Volume 34, Number 3, Page(s) 255-258     
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DOI: 10.5146/tjpath.2015.01359
Cloacogenic Adenocarcinoma of the Vulva: A Case Report and Review of the Literature
Merih TEPEOĞLU1, Halit ÜNER2, A.Nihan HABERAL1, Özlem ÖZEN1, Esra KUŞÇU3
1Department of Pathology, Başkent University School of Medicine, Ankara, Turkey
2Hacettepe University School of Medicine, Ankara, Turkey
3Department of Obstetrics and Gynecology, Başkent University School of Medicine, Ankara, Turkey
Keywords: Vulvar neoplasms, Adenocarcinoma, Cloacogenic, Metastasis

Primary adenocarcinoma of the vulva, unrelated to the native glands of perineum is an extremely rare neoplasm. Despite awareness of this lesion for over 40 years, the origin is not beyond speculation. The most reasonable hypothesis is based on the remnants of cloacal differentiation during early days of life. Here we report the case of a 60-year-old patient with a vulvar mass, who underwent partial vulvectomy and bilateral regional lymph node dissection. The tumor was composed of papillary and complex glandular structures and exhibited diffuse positivity for cytokeratin 20 and polyclonal CEA, CDX2, and focal positivity with cytokeratin 7. Unlike the indolent behavior of this malignant neoplasm according to the literature, we found two metastatic inguinal lymph nodes. She did not receive adjuvant therapy and is still alive, free of disease 38 months after surgery. We present different aspects of vulvar adenocarcinomas with a case report.

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