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2019, Volume 35, Number 2, Page(s) 157-161     
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DOI: 10.5146/tjpath.2017.01407
Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland
Deniz ARIK1, Emine DÜNDAR1, Evrim YILMAZ1, Cumhur SİVRİKOZ2
1Department of Pathology, Eskisehir Osmangazi University, Medicine Faculty, ESKİŞEHİR, TURKEY
2Department of Thorax Surgery, Eskisehir Osmangazi University, Medicine Faculty, ESKİŞEHİR, TURKEY
Keywords: Water-clear cell, Adenoma, Ectopic tissue, Mediastinum, Parathyroid gland

Water-clear cell adenoma of the parathyroid gland is a rare neoplasm that consists of cells with abundant clear-pink cytoplasm. There have only been 19 cases reported in the English literature. Here we report a case of water-clear cell adenoma of the mediastinal parathyroid gland. A 70-year-old male patient presented to the hospital with back pain and a mediastinal mass 6 cm in size was detected. After excision and microscopic evaluation, uniform, large clear cells with fine cytoplasmic vacuolization, without nuclear atypia, and arranged in solid and acinar patterns were revealed. The cells formed nests that were separated by fine fibrovascular septae and stained positively with anti-parathyroid hormone. To the best of our knowledge, this has not been previously reported in this location. In the differential diagnosis of clear cell lesions of the mediastinum, water-clear cell parathyroid adenoma should be considered.

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