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2008, Volume 24, Number 1, Page(s) 014-018     
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Concordance of nuclear morphometric analysis with Fuhrman nuclear grade and pathologic stage in conventional renal cell carcinoma
Sibel BEKTAŞ1, Figen BARUT1, Gürkan KERTİŞ1, Burak BAHADIR1, Banu DOĞAN GÜN1, Nilüfer ONAK KANDEMİR1, Nimet KARADAYI2, Şükrü Oğuz ÖZDAMAR1
1Zonguldak Karaelmas University, School of Medicine, Department of Pathology, ZONGULDAK
2Lutfi Kirdar Kartal Training and Research Hospital, Department of Pathology, ZONGULDAK
Keywords: Konvansiyonel böbrek hücreli karsinom, Fuhrman nükleer derece, patolojik evre, nükleer morfometri

Quantitative image analysis has been applied to renal cancers for diagnostic and prognostic purposes. The aim of this study was to investigate whether there is any correlation between the results of morphometric measurements and Fuhrman nuclear grade, pathologic stage and size of conventional (clear cell) renal cell carcinoma. Morphometric nuclear parameters such as roundness factor, form ellipse, area, length, breadth and perimeter were evaluated in hematoxylin-eosin stained slides of 37 conventional renal cell carcinomas by using computer assisted image analysis system. The relationship between Fuhrman nuclear grade, pathologic stage, tumor size and morphometric results were determined by correlation analysis. Mean nuclear areas correlated with pathologic stages (r:0.413, p=0.05) and with Fuhrman nuclear grade (r:0.588, p=0.01). Mean nuclear length correlated with pathologic stage (r:0.446, p=0.01) and with Fuhrman nuclear grade (r:0.580, p=0.01). Mean nuclear breadth were correlated with pathologic stage (r:0.377, p=0.05) and with Fuhrman nuclear grade (r:0.544, p=0.01) and with tumor size (r:0.366, p=0.05). Mean nuclear perimeter correlated with pathologic stage (r:0.449, p=0.01) and Fuhrman nuclear grade (r:0.593, p=0.01). Mean nuclear roundness factor correlated with pathologic stage (r:0.418, p=0.05) and Fuhrman nuclear grade (r:0.456, p=0.01). In this study, the relative concordance of morphometric results and pathologic stage and Fuhrman nuclear grade, exhibited the importance of nuclear morphometric analysis in the assessment of conventional renal cell carcinoma.

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