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2009, Volume 25, Number 2, Page(s) 013-019     
[ Abstract (Turkish) ] [ PDF ] [ Similar Articles ]
DOI: 10.5146/tjpath.2009.00966
Cox-2 Expression and Microvessel Density in Clear Cell Type Renal Cell Carcinoma
Hasan GÜÇER1, Elife ŞAHAN2, Ayşenur AKYILDIZ İĞDEM2, Ü. Seza TETİKKURT2, Nusret ERDOĞAN2
1S.B. Kars Devlet Hastanesi, Patoloji Bölümü, KARS, TÜRKİYE
2Taksim Eğitim ve Araştırma Hastanesi, Patoloji Bölümü, İSTANBUL, TÜRKİYE
Keywords: Renal cell carcinoma, COX-2, Immunohistochemistry, Microvessel density

Objective: Overexpression of cyclooxygenase-2 (COX-2) and its association with angiogenesis have been shown in various carcinomas. In this study, we investigated COX-2 expression in clear cell type renal cell carcinoma and its association with microvessel density and various clinicopathologic parameters.

Material and Method: Fifty cases of clear cell type renal cell carcinoma that underwent radical nephrectomy were included in this study. Th e status of COX-2 expression was examined immunohistochemically. Microvessel density in the neoplasm was estimated using the computerized image-analizer system. We evaluated the correlation between COX-2 expression, microvessel density and clinicopathologic findings.

Results: COX-2 expression was observed in 76% of the cases. Th ere was no association between COX-2 expression and microvessel density, age, sex, tumor size, nuclear grade and stage (p>0.05).

Conclusion: Most clear cell type renal cell carcinomas expressed COX-2, but there was no relationship between COX-2 and various clinicopathologic parameters. Similar studies to explore therapeutic agents that target these specialities can be useful in the treatment of renal cell carcinomas which show COX-2 expression and high vascularity.


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