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2015, Volume 31, Number 3, Page(s) 230
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DOI: 10.5146/tjpath.2015.01308
Molecular Biology for HPV Typing in Focal Epithelial Hyperplasia
Gian Paolo BOMBECCARI, Gianpaolo GUZZI, Francesco PALLOTTI, Francesco SPADARI, Aldo Bruno GIANNI
1Department of Biomedical, Surgical, and Dental Sciences, Unit of Oral Pathology and Medicine, University of Milan, Via Della Commenda MILAN, ITALY
2Italian Association for Metals and Biocompatibility Research, A.I.R.M.E.B., MILAN, ITALY
3Unit of Anatomical Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, MILAN, ITALY
4Department of Biomedical, Surgical, and Dental Sciences, Unit of Oral Pathology and Medicine, University of Milan, MILAN, ITALY
5Maxillo-Facial and Odontostomatology Unit, Fondazione Cą Granda IRCCS Ospedale Maggiore Policlinico, Department of Biomedical, Surgical and Dental Sciences, University of Milan, MILAN, ITALY
Introduction
To the Editor,

Parichehr Ghalayani and colleagues (Volume 31, Number 1, Pages:060-063) report three interesting cases of focal epithelial hyperplasia (FEH) diagnosed through clinical and microscopic analysis1. We would like to emphasize that, although the age and ethnicity of the patient may support the clinical suspicion of FEH, the histopathological features of FEH might be similar to that of condyloma acuminatum and oral squamous cell papilloma2.

Detection of specific HPV genotype by polymerase chain reaction (PCR) is a specific and sensitive method to confirm the diagnosis of FEH2. Susceptible HPV subtypes of condyloma acuminatum and oral squamous cell papilloma are most frequently 6,11,16 and 183. Human papillomavirus-13 in the children or 32 in adult patients are viral subtypes implicated in most patients with FEH diagnosis (>90%)3. When suspicion of condyloma acuminatum or venereal warts is raised, particularly in children, accurate genotyping diagnosis should be mandatory to rule out suspected of sexual abuse.

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  • Introduction
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  • References

    1) Ghalayani P, Tavakoli P, Eftekhari M, Haghighi MA. Oral focal epithelial hyperplasia: Report of three cases. Turk Patoloji Derg. 2015;31:60-3.

    2) Said AK, Leao JC, Fedele S, Porter SR. Focal epithelial hyperplasiaan update. J Oral Pathol Med. 2013;42:435-42.

    3) Liu N, Li Y, Zhou Y, Zeng X. Focal epithelial hyperplasia (Heck's disease) in two Chinese females. Int J Oral Maxillofac Surg. 2012;41:1001-4.

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