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2000, Volume 16, Number 3-4, Page(s) 093-096
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Nusret AKPOLAT, Fatma Hüsniye DİLEK, Beyhan ERYONUCU
Fırat Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, Kocatepe Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, Yüzüncü Yıl Üniversitesi Tıp Fakültesi,Kardiyoloji Anabilim Dalı
Cardiac angiosarcomas are rare and accounting for 8.8 % of primary cardiac tumors. Clinically, incidence is equal in men and women and most patients are in the fourth decade. It classically located in the right atrium. Often, they are diagnosed only at autopsy. Prognose is poor and survival for two years is 17%. The patient, who is 30 years old female was admitted to hospital with following complains; cough for 6 months, chest pain, dispnea and weakness. On physical examination, cyanosis, crepitane rale of the left lobe of lung, hepatomegaly, ascites, pretibial edema were detected. There was no specific finding on laboratory tests. EKG showed low voltage and negative T in all derivations. The patient died from acute cardiac tamponade. Postmortem examination showed that the tumor which was in right atrium had diffuse growth pattern and diffuselly infiltrated the surrounding structures including the pericardial space. Microscopic examination disclosed that the tumor had extensive areas of necrosis and hemorrhage. Lung showed extensive metastases which had peculiar tendency to localize around vessels and also tumor thrombous was observed. By immunohistochemistry tumoral cells were positive for vimentin, FVIII related antigen and negative for cytokeratin. Herein, we discussed the cardiac angiosarcomas in view of the literature.
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