Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2023, Vol 39, Num, 3     (Pages: 206-211)

Lobomycosis in a Post-Covid 19 Patient: A Case Report and Review of Literature

Sateesh S CHAVAN 1, Thotadamane Nagaraja CHANDRASHEKHAR 2

1 Departments of Pathology, Karnataka Institute of Medical Sciences, KARNATAKA, INDIA
2 Shivamogga Institute of Medical Sciences, KARNATAKA, INDIA

DOI: 10.5146/tjpath.2023.01604
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Aim: To document a case of lobomycosis and to discuss its epidemiology & diagnosis.

Case Report: A 53-year-old male presented with a history of nasal congestion, nasal discharge, and epistaxis following Covid 19 infection. On physical examination, there was necrotic slough in the nasal vestibule near the inferior turbinate. Scrapings and punch biopsy were taken from the lesion. Hematoxylin-eosin-stained sections showed necrotic and mucoid areas with mixed inflammatory cell infiltration and numerous budding yeasts 3- 7μm diameter in singles, and small clusters with single narrow based budding as well as multiple budding including sequential budding forming “chains of yeasts”. A diagnosis of Lobomycosis was made. Yeasts of lobomycosis are often confused with other yeasts such as P. brasiliensis, Candida spp., B. dermatitidis, and Cryptococci, but characteristic ‘sequential budding’ with a ‘chain of yeasts” aid in the final diagnosis. Demonstration of yeasts with characteristic chains either in tissue sections or in potassium hydroxide (KOH) preparation of scraped material, exudate, or exfoliative cytology is the mainstay in the diagnosis as the organisms are uncultivable in vitro in culture medium.

Keywords : Lobomycosis, Lacaziosis, Chain of yeasts, Sequential budding, Connecting tubes