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2011, Volume 27, Number 2, Page(s) 144-148
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DOI: 10.5146/tjpath.2011.01063 |
Histopathological Correlation of Squamous Cell Abnormalities Detected on Cervical Cytology |
Remzi ABALI1, Besim Haluk BACANAKGİL2, Serdar ÇELİK2, Özlem ARAS2, Pelin KOCA2, Birtan BORAN2, Nevra DURSUN3 |
1Department of Obstetrics and Gynaecology Namık Kemal University, Faculty of Medicine, TEKİRDAĞ, TURKEY
2Department of Obstetrics and Gynaecology, M.H. İstanbul Education and Research Hospital, İSTANBUL, TURKEY
3Department of Pathology, M.H. İstanbul Education and Research Hospital, İSTANBUL, TURKEY |
Keywords:
Cytology, Cervical smears, Papanicolaou test, Pathology |
Objective: To investigate the correlation between cytology and
cervical biopsy in patients with squamous cell abnormality on
cervical cytology.
Material and Method: The cervical smears diagnosed in our clinic
between 2005-2008 were reviewed retrospectively. Cases which
exhibited squamous cell abnormality (n: 374) were evaluated.
Results: The mean age was 45.15±10.78. In the cytopathological
results, 256 (68.4%) ASC-US, 21 (5.6%) ASC-H, 31 (8.2%) LSIL, 48
(12.8%) HSIL, and 8 (4.8%) invasive carcinomas were diagnosed.
Histopathological results were 213 (57%) nonneoplastic, 85 (22.7%)
CIN I, 14 (3.7%) CIN II, 34(9.0%) CIN III and 28 (7.5%) invasive
squamous cell carcinomas. Including all squamous cell abnormalities,
the sensitivity of the smear test in CIN I and higher grade lesions
was 56.95% and the false positivity was 43.04%. Excluding ASC-US
and ASC-H lesions, the sensitivity of the smear test was 77.31%
and the false positivity was 22.68%. After evaluating cervical cytohistopathological
correlation, the positive predictive value was found
to be 100% in invasive carcinoma, 62% in HSIL and 38% in LSIL.
Conclusion: As the grade of cytopathological result increases, the
correlation between biopsy and the smear test also increases. The
high sensitivity of the cervical smear test for high-grade lesions shows
that it is an effective screening test.
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